Expert Advice on Lexapro Weight Gain: What You Should Know

Expert Advice on Lexapro Weight Gain: What You Should

Know

Antidepressant Lexapro (escitalopram) has long been associated with weight gain. Reports have consistently highlighted that some individuals experience weight changes while on certain antidepressants. Recent research aims to clarify which antidepressants are most linked to weight gain. Published in the Annals of Internal Medicine, the study analyzed electronic health records from over 183,000 patients who used antidepressants for the first time, tracking their weight over two years.

Key Findings from the Study

The study revealed that after six months, patients taking Lexapro, Paxil, or Cymbalta had a 10% to 15% higher risk of gaining weight (defined as at least 5% of their baseline weight) compared to those on Zoloft. However, taking an antidepressant doesn't guarantee weight gain for everyone.

Understanding Lexapro Weight Gain

The relationship between depression, anxiety, and weight is complex and varies for each person. Joshua Petimar, Sc.D., lead author of the study and assistant professor at Harvard Medical School, explains, “Some people who experience depression or anxiety may gain weight, while others may lose weight or not experience any major weight changes.”

Factors influencing weight changes include a person’s relationship with food and their history with stress management. “Stress can lead to weight gain, but it can also lead to weight loss,” says Thea Gallagher, Psy.D., from NYU Langone Health.

Why Lexapro Might Cause Weight Gain

Selective serotonin reuptake inhibitors (SSRIs) are a type of antidepressants that raise serotonin levels in the body. Lexapro is one of these drugs.  Serotonin, often called a “feel-good chemical,” also plays a role in appetite and weight control, potentially causing weight gain in some individuals. “There are a lot of serotonin receptors in the gut,” Gallagher notes, highlighting the connection between mood and the gastrointestinal system.

Dr. Mir Ali, a bariatric surgeon, mentions that improved mood from antidepressants may lead to increased eating and subsequent weight gain. This phenomenon is not unique to Lexapro; similar effects have been observed with other SSRIs like Zoloft and Prozac.

Strategies to Avoid Weight Gain on Antidepressants

Each person's response to antidepressants is unique. Hillary Ammon, Psy.D., advises discussing concerns with a doctor. It is feasible to select an antidepressant that addresses symptoms without causing unintended weight gain, according to Petimar. "Some antidepressants raise the risk of significant weight gain more than others."

If you’re already on an antidepressant and notice weight gain, consult your doctor about adjusting your treatment or lifestyle. Prozac and Wellbutrin are often associated with less weight gain and might be alternatives to consider. Dr. Gail Saltz suggests discussing dosage adjustments with your doctor, as a lower dose may reduce weight gain while remaining effective.

Conclusion

Understanding the potential for weight gain with Lexapro and other antidepressants is crucial. Open communication with healthcare providers can help tailor treatment plans that address both mental health symptoms and weight management concerns. By making informed choices and maintaining a healthy lifestyle, patients can minimize unwanted side effects while benefiting from their medication.

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FAQs

1. Which antidepressants are most likely to cause weight gain?

• Lexapro, Paxil, and Cymbalta have been found to increase the risk of weight gain by 10% to 15% compared to Zoloft.

2. Can taking Lexapro guarantee weight gain?

• No, not everyone will gain weight on Lexapro. Weight changes depend on individual responses to the medication.

3. Why does Lexapro cause weight gain in some people?

• Lexapro increases serotonin levels, which can affect appetite and weight control. Improved mood may also lead to increased eating.

4. How can I avoid gaining weight on antidepressants?

• Discuss your concerns with your doctor, who can help find the best medication for you. Consider lifestyle changes, such as a healthy diet and regular exercise, and possibly consulting a nutritionist.

5. Are there antidepressants less likely to cause weight gain?

• Prozac and Wellbutrin are often linked to less weight gain compared to other SSRIs.